Radiometals:
- B. Saeedi, H. Yang, V. Radchenko, A High Separation Factor, High Molar Activity, and Inexpensive Purification Method for the Production of Pure 165Er, Inorg. Chem. 2024, In press.
- L. Wharton, S. W. McNeil, H. Merkens, Z. Yuan, M. Van de Voorde, G. Engudar, A. Ingham, H. Koniar, C. Rodríguez-Rodríguez, V. Radchenko, M. Ooms, P. Kunz, F. Bénard, P. Schaffer, H. Yang, Preclinical Evaluation of [155/161Tb]Tb-Crown-TATE—A Novel SPECT Imaging Theranostic Agent Targeting Neuroendocrine Tumours, Molecules 2023, 28, 3155.
- H. Koniar, S. McNeil, L. Wharton, A. Ingham, M. Van de Voorde, M. Ooms, S. Sekar, C. Rodríguez-Rodríguez, P. Kunz, V. Radchenko, A. Rahmim, C. Uribe, H. Yang, P. Schaffer, Performance assessment of quantitative preclinical SPECT imaging with 155Tb and 161Tb. Nucl. Med. Biol. 2023, 126–127, 108623.
- I. Carbo-Bague, C. Li, B. L. McNeil, Y. Gao, A. W. McDonagh, M. Van De Voorde, M. Ooms, P. Kunz, H. Yang, V. Radchenko, G. Schreckenbach, C. F. Ramogida, Comparative Study of a Decadentate Acyclic Chelate, HOPO-O10, and Its Octadentate Analogue, HOPO-O8, for Radiopharmaceutical Applications, Inorg. Chem. 2023, 62, 20549.
- P. Kunz, J. Lassen, C. Andreoiu, F. H. Garcia, H. Yang, V. Radchenko, Understanding radioactive ion beam production at ISAC through yield measurements and simulations, Nucl. Instruments Methods Phys. Res. Sect. B Beam Interact. with Mater. Atoms, 2023, 541, 117–120.
- S. W. McNeil, M. Van de Voorde, C. Zhang, M. Ooms, F. Bénard, V. Radchenko, H. Yang, A simple and automated method for 161Tb purification and ICP-MS analysis of 161Tb, EJNMMI Radiopharm. Chem. 2022 71 2022, 7, 1–17.
- L. Wharton, C. Zhang, J. Zeisler, C. Rodríguez-Rodríguez, M. Osooly, V. Radchenko, H. Yang, K. S. Lin, F. Bénard, P. Schaffer, C. Orvig, H3TPAN-Triazole-Bn-NH2: Tripicolinate Clicked-Bifunctional Chelate for [225Ac]/[111In] Theranostics, Bioconjug. Chem. 2022, 33, 2381.
- L. Wharton, M. D. G. Jaraquemada-Peláez, C. Zhang, J. Zeisler, C. Rodríguez-Rodríguez, M. Osooly, V. Radchenko, H. Yang, K. S. Lin, F. Bénard, P. Schaffer, C. Orvig, H4picoopa─Robust Chelate for 225Ac/111In Theranostics, Bioconjug. Chem. 2022, 33, 1900–1921.
- H. Koniar, C. Rodríguez-Rodríguez, V. Radchenko, H. Yang, P. Kunz, A. Rahmim, C. Uribe, P. Schaffer, Performance assessment of quantitative preclinical SPECT imaging with 155Tb and 161Tb, Phys. Med. Biol. 2022, 67, 185009.
- L. Southcott, L. Wharton, J. Rousseau, H. Merkens, H. Yang, F. Bénard, C. Orvig, Trastuzumab-conjugated oxine-based ligand for [89Zr]Zr4+ immunoPET. J. Inorg. Biochem. 2022, 235, 111936.
- A. W. McDonagh, B. L. McNeil, J. Rousseau, R. J. Roberts, H. Merkens, H. Yang, F. Bénard, C. F. Ramogida, Development of a multi faceted platform containing a tetrazine, fluorophore and chelator: synthesis, characterization, radiolabeling, and immuno-SPECT imaging. EJNMMI Radiopharm. Chem. 2022, 7, 1–24.
- A. Baimukhanova, G. Engudar, G. Marinov, E. Kurakina, J. Dadakhanov, D. Karaivanov, H. Yang, C. F. Ramogida, P. Schaffer, E. P. Magomedbekov, D. Filosofov, V. Radchenko, An alternative radiochemical separation strategy for isolation of Ac and Ra isotopes from high energy proton irradiated thorium targets for further application in Targeted Alpha Therapy (TAT), Nucl. Med. Biol. 2022, 112–113, 35–43.
- L. Wharton, C. Zhang, H. Yang, J. Zeisler, V. Radchenko, C. Rodríguez-Rodríguez, M. Osooly, B. O. Patrick, K. S. Lin, F. Bénard, P. Schaffer, C. Orvig, Bi3+/[111In]In3+-neunpa-cycMSH: Theranostic Radiopharmaceutical Targeting Melanoma-Structural, Radiochemical, and Biological Evaluation. Bioconjug. Chem. 2022, 33, 505–522.
- A. Hu, V. Brown, S. N. Macmillan, V. Radchenko, H. Yang, L. Wharton, C. F. Ramogida, J. J. Wilson, Chelating the Alpha Therapy Radionuclides 225Ac3+and 213Bi3+with 18-Membered Macrocyclic Ligands Macrodipa and Py-Macrodipa, Inorg. Chem. 2022, 61, 801–806.
- H. Yang, J. J. Wilson, C. Orvig, Y. Li, D. S. Wilbur, C. F. Ramogida, V. Radchenko, P. Schaffer, Harnessing alpha-emitting radionuclides for therapy – radiolabeling method review, J. Nucl. Med., 2022, 63, 5.
- L. Southcott, X. Wang, N. Choudhary, L. Wharton, B. O. Patrick, H. Yang, K. Zarschler, M. Kubeil, H. Stephan, M. de G. Jaraquemada-Peláez, C. Orvig. H2pyhox - Octadentate Bis(pyridyloxine). Inorg. Chem, 2021, 60, 12186.
- L. Southcott, X. Wang, L. Wharton, H. Yang, V. Radchenko, M. Kubeil, H. Stephan, M. de G. Jaraquemada-Peláez, C. Orvig, High Denticity Oxinate-linear-backbone Chelating Ligand for Diagnostic Radiometal Ions [111In]In3+ and [89Zr]Zr4+. Dalton Trans., 2021, 50, 3874.
- S. Suárez-García, T. V. F. Esposito, J. Neufeld-Peters, M. Bergamo, H. Yang, K. Saatchi, P. Schaffer, U. O. Häfeli, D. Ruiz-Molina, C. Rodríguez-Rodríguez, F. Novio, Hybrid Metal−Phenol Nanoparticles with Polydopamine-like Coating for PET/SPECT/CT Imaging. ACS Appl. Mater. Interfaces, 2021, 13, 10705.
- B. L. McNeil, A. K. H. Robertson, W. Fu, H. Yang, C. Hoehr, C. F. Ramogida, P. Schaffer, Production, purification and radiolabeling of the 203Pb/212Pb theranostic pair, EJNMMI Radiopharm. Chem., 2021, 6, 6.
- H. Yang, F. Gao, B. McNeil, C. Zhang, Z. Yuan, S. Zeisler, J. Kumlin, J. Zeisler, F. Bénard, C. Ramogida, P. Schaffer, Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide, EJNMMI Radiopharm. Chem., 2021, 6, 3.
- H. Yang, C. Zhang, Z. Yuan, C. Rodriguez‐Rodriguez, A. Robertson, V. Radchenko, R. Perron, D. Gendron, P. Causey, F. Gao, F. Bénard, P. Schaffer, P. Synthesis and Evaluation of a Macrocyclic Actinium‐225 Chelator, Quality Control and In Vivo Evaluation of 225Ac‐crown‐αMSH Peptide. Chem. Eur. J. 2020, 26, 11435–11440.
- A. K. H. Robertson, B. L. McNeil, H. Yang, D. Gendron, R. Perron, V. Radchenko, S. Zeisler, P. Causey, P. Schaffer, 232Th-Spallation-Produced 225Ac with Reduced 227Ac Content. Inorg. Chem. 2020, 59, 12156–12165 (featured on cover page).
- C. F. Ramogida, A. K. H. Robertson, U. Jermilova, C. Zhang, H. Yang, P. Kunz, J. Lassen, I. Bratanovic, V. Brown, L. Southcott, et al., Evaluation of polydentate picolinic acid chelating ligands and an α-melanocyte-stimulating hormone derivative for targeted alpha therapy using ISOL-produced 225Ac, EJNMMI Radiopharm. Chem. 2019, 4, 1–20.
- G. Langille, H. Yang, S. K. Zeisler, C. Hoehr, T. Storr, C. Andreoiu, P. Schaffer, Low energy cyclotron production and cyclometalation chemistry of iridium-192, Appl. Radiat. Isot. 2016, 115, 81–86
- C. Hoehr, E. Oehlke, F. Benard, C. J. Lee, X. Hou, B. Badesso, S. Ferguson, Q. Miao, H. Yang, K. Buckley, et al., 44gSc production using a water target on a 13MeV cyclotron, Nucl. Med. Biol. 2014, 41, 401–406.
- M. Colovic, H. Yang, L. Southcott, H. Merkens, N. Colpo, F. Bénard, P. Schaffer, J. Comparative Evaluation of [18F]5-Fluoroaminosuberic Acid and (4S)-4-3-[18F]fluoropropyl)-l-Glutamate as System xC--Targeting Radiopharmaceuticals J. Nucl. Med. 2023, 64, 1314–1321.
- M. Čolović, H. Yang, H. Merkens, N. Colpo, F. Bénard, P. Schaffer. Non-invasive Use of Positron Emission Tomography to Monitor Diethyl maleate and Radiation-Induced Changes in System xC− Activity in Breast Cancer. Mol. Imaging Biol. 2019, 21, 1107–1116.
- Z. Yuan, H. Yang, N. Malik, M. Čolović, D. S. Weber, D. Wilson, F. Bénard, R. E. Martin, J. J. Warren, P. Schaffer, et al., Electrostatic Effects Accelerate Decatungstate-Catalyzed C-H Fluorination Using [18F]- And [19F]NFSI in Small Molecules and Peptide Mimics. ACS Catal. 2019, 9, 8276–8284.
- M. B. Nodwell, H. Yang, H. Merkens, N. Malik, M. Čolović, B. Wagner, R. E. Martin, F. Bénard, P. Schaffer, R. Britton. 18F-branched-chain amino acids: Structure-activity relationships and PET imaging potential. J. Nucl. Med. 2019, 60, 1003–1009. (Alavi-Mandell Award)
- M. Čolović, H. Yang, H. Merkens, N. Colpo, F. Bénard, P. Schaffer, The Effect of Chirality on the Application of 5-[18F]Fluoro-Aminosuberic Acid ([18F]FASu) for Oxidative Stress Imaging. Mol. Imaging Biol. 2020, 22, 873-882.
- J. K. M. Lim, A. Delaidelli, S. W. Minaker, H. F. Zhang, M. Colovic, H. Yang, G. L. Negri, S. von Karstedt, W. W. Lockwood, P. Schaffer, et al., Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance, Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 9433–9442.
- M. Čolović, E. Rousseau, Z. Zhang, J. Lau, C. Zhang, H. T. Kuo, H. Yang, P. Schaffer, F. Bénard, K. S. Lin, Synthesis and evaluation of an 18F-labeled boramino acid analog of aminosuberic acid for PET imaging of the antiporter system xC−, Bioorganic Med. Chem. Lett. 2018, 28, 3579–3584.
- Z. Yuan, M. B. Nodwell, H. Yang, N. Malik, H. Merkens, F. Bénard, R. E. Martin, P. Schaffer, R. Britton, Site-Selective, Late-Stage C−H 18F-Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging, Angew. Chem. Int. Ed. 2018, 57, 12733–12736.
- H. Yang, B. Tam, M. Čolović, L. Southcott, H. Merkens, F. Bénard, P. Schaffer, Addressing Chirality in the Structure and Synthesis of [18F]5-Fluoroaminosuberic Acid ([18F]FASu), Chem. Eur. J. 2017, 23, 11100–11107.
- M. B. Nodwell, H. Yang, M. Čolović, Z. Yuan, H. Merkens, R. E. Martin, F. Bénard, P. Schaffer, R. Britton. 2017. “18F-Fluorination of Unactivated C-H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents, J. Am. Chem. Soc. 2017, 139, 3595–98.
- H. Yang, S. Jenni, M. Colovic, H. Merkens, C. Poleschuk, I. Rodrigo, Q. Miao, B. F. Johnson, M. J. Rishel, V. Sossi, et al., 18F-5-Fluoroaminosuberic acid as a potential tracer to gauge oxidative stress in breast cancer models, J. Nucl. Med. 2017, 58, 367–373.
- S. A. Fiel, H. Yang, P. Schaffer, S. Weng, J. A. H. Inkster, M. C. K. Wong, P. C. H. Li, Magnetic Droplet Microfluidics as a Platform for the Concentration of [18F]Fluoride and Radiosynthesis of Sulfonyl [18F]Fluoride, ACS Appl. Mater. Interfaces 2015, 7, 12923–12929.
- H. Yang, Q. Miao, B. F. Johnson, M. J. Rishel, V. Sossi, K. Dinelle, F. Bénard., D. T. Yapp, J. M. Webster, P. Schaffer, A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the xC- transporter, Bioorganic Med. Chem. Lett. 2014, 24, 5512–5515.
- J. M. Webster, C. A. Morton, B. F. Johnson, H. Yang, M. J. Rishel, B. D. Lee, Q. Miao, C. Pabba, D. T. Yapp, P. Schaffer, Functional imaging of oxidative stress with a novel PET imaging agent, 18f-5-fluoro-l-aminosuberic acid, J. Nucl. Med. 2014, 55, 657–664. (Top 3 Basic Science Manuscript award)
- J. R. Crawford, A. K. H. Robertson, H. Yang, C. Rodríguez-Rodríguez, P. L. Esquinas, P. Kunz, S. Blinder, V. Sossi, P. Schaffer, T. J. Ruth, Evaluation of 209 At as a theranostic isotope for 209 At-radiopharmaceutical development using high-energy SPECT, Phys. Med. Biol. 2018, 63, 045025.
- J. R. Crawford, H. Yang, P. Kunz, D. S. Wilbur, P. Schaffer, T. J. Ruth, Development of a preclinical 211Rn/211At generator system for targeted alpha therapy research with 211At, Nucl. Med. Biol. 2017, 48, 31–35.
- J. R. Crawford, P. Kunz, H. Yang, P. Schaffer, T. J. Ruth, 211Rn/211At and 209At production with intense mass separated Fr ion beams for preclinical 211At-based α-therapy research, Appl. Radiat. Isot. 2017, 122, 222–228.
- H. Yang, F. Altvater, A. D. de Bruijn, C. K. McLaughlin, P. K. Lo, H. F. Sleiman, Chiral Metal-DNA Four-Arm Junctions and Metalated Nanotubular Structure, Angew. Chem. Int. Ed. 2011, 50, 4620–4623.
- H. Yang, P. K. Lo, C. K. McLaughlin, G. D. Hamblin, F. A. Aldaye, H. F. Sleiman, Self-assembly of metal-DNA triangles and DNA nanotubes with synthetic junctions. Methods Mol. Biol. 2011, 749, 33–47.
- C. K. McLaughlin, G. D. Hamblin, F. A. Aldaye, H. Yang, H. F. Sleiman, A facile, modular and high yield method to assemble three-dimensional DNA structures. Chem. Commun. 2011, 47, 8925–8927.
- H. Yang, K. L. Metera, H. F. Sleiman, DNA modified with metal complexes: Applications in the construction of higher order metal-DNA nanostructures. Coord. Chem. Rev. 2010, 254, 2403–2415.
- Y. Wen, C. K. McLaughlin, P. K. Lo, H. Yang, H. F. Sleiman, Stable gold nanoparticle conjugation to internal DNA positions: Facile generation of discrete gold nanoparticle-DNA assemblies. Bioconjug. Chem. 2010, 21, 1413–1416.
- H. Yang, A. Z. Rys, C. K. McLaughlin, H. F. Sleiman, Templated Ligand Environments for the Selective Incorporation of Different Metals into DNA. Angew. Chem. Int. Ed. 2009, 48, 9919–9923.
- H. Yang, C. K. McLaughlin, F. A. Aldaye, G. D. Hamblin, A. Z. Rys, I. Rouiller, H. F. Sleiman, Metal-nucleic acid cages. Nat. Chem. 2009, 1, 390–396.
- H. Yang, H. F. Sleiman, Templated Synthesis of Highly Stable, Electroactive, and Dynamic Metal–DNA Branched Junctions. Angew. Chem. Int. Ed. 2008, 47, 2443–2446.
- Y.-Q. Liu, H. Yang, X. Tian, Design, Synthesis and Biological Evaluation of Novel Etoposide Analogues as Cytotoxic Agents. Chinese J. Chem. 2006, 24, 785–790.
- X. Tian, H. Yang, Studies on separation of C-4 diastereomers of Podophyllum analogues by HPLC. Chinese J. Anal. Lab. 2003, 22, 131–133.
- H. Yang, X. Tian, Synthesis and anti-tumor activity of novel podophyllum analogues. J. Lanzhou Univ. (Natural Sci). 2002, 38, 101–105.